What Causes Restless Leg Syndrome and Who Is Most at Risk?

June 16, 2026

If you’ve ever felt an uncomfortable urge to move your legs while trying to relax or fall asleep, you may have experienced symptoms of restless leg syndrome. While occasional discomfort can happen to anyone, persistent symptoms may point to a neurological sleep-related condition known as restless leg syndrome (RLS).

At Sleep Wellness Center, we help patients understand how restless leg syndrome can affect sleep quality, energy levels, and overall health. Because symptoms often worsen at night, RLS can make it difficult to fall asleep and stay asleep consistently.

What is Restless Leg Syndrome?

Restless leg syndrome is a condition that causes uncomfortable sensations in the legs along with a strong urge to move them. Symptoms most commonly occur during periods of rest, especially in the evening or at night. People with restless leg syndrome often describe sensations such as:

  • Tingling
  • Crawling
  • Aching
  • Pulling
  • Throbbing
  • “Pins and needles” feelings

Moving the legs usually provides temporary relief, but symptoms often return once movement stops.

What Causes Restless Leg Syndrome?

The exact cause of restless leg syndrome is not always clear, but researchers believe that it is related to how the brain processes dopamine, a chemical involved in muscle movement and nerve signaling. Many factors may contribute to restless leg syndrome, including:

Genetics and Family History

Restless leg syndrome often runs in families. People with a close relative who has RLS may have a higher likelihood of developing symptoms themselves. 

Iron Deficiency

Low iron levels are commonly associated with restless leg syndrome. Iron plays an important role in dopamine function, and deficiencies may contribute to symptom development. 

Pregnancy

Some women experience restless leg syndrome during pregnancy, particularly during the third trimester. Symptoms often improve after delivery. 

Chronic Health Conditions

Certain medical conditions may increase the risk of developing restless leg syndrome, including:

  • Kidney disease
  • Diabetes
  • Peripheral neuropathy
  • Parkinson’s disease

Lifestyle and Sleep Factors

Some lifestyle habits and sleep disruptions may worsen restless leg syndrome symptoms, including:

  • Sleep deprivation
  • High caffeine intake
  • Alcohol use
  • Certain medications
  • Irregular sleep schedules

Who Is Most at Risk for Restless Leg Syndrome?

While restless leg syndrome can affect anyone, some individuals may be at higher risk. 

Adults Over 40

RLS becomes more common with age, although younger adults and children can also experience symptoms. 

Women

Women are more likely than men to develop restless leg syndrome, especially during pregnancy or hormonal changes. 

Shift Workers and Poor Sleepers

People with inconsistent sleep schedules or chronic sleep deprivation may notice more severe symptoms, particularly at night when the body is trying to rest. 

Individuals with Underlying Health Conditions

Conditions that affect circulation, nerves, or brain signaling may increase the likelihood of restless leg syndrome symptoms developing over time. 

How Restless Leg Syndrome Affects Sleep

Because symptoms tend to worsen during periods of inactivity, bedtime is often when restless leg syndrome becomes most disruptive.

People with RLS may experience:

  • Difficulty falling asleep
  • Frequent nighttime awakenings
  • Poor sleep quality
  • Excessive daytime fatigue
  • Difficulty concentrating

Over time, interrupted sleep can impact mood, energy levels, work performance, and overall quality of life.

When Symptoms Shouldn’t Be Ignored

Occasional leg discomfort is common, but persistent symptoms that interfere with sleep should not be ignored. Many people normalize chronic fatigue without realizing that restless leg syndrome may be contributing to their sleep disruption.

If symptoms occur regularly, worsen at night, or interfere with your ability to sleep comfortably, it may be time for a professional evaluation.

How a Sleep Specialist Can Help

At Sleep Wellness Center, we evaluate symptoms that may be affecting your sleep quality and overall health. Because restless leg syndrome can overlap with other sleep disorders, a sleep evaluation can help identify what’s contributing to nighttime discomfort and fatigue.

Depending on symptoms, providers may recommend:

  • Reviewing sleep habits and lifestyle factors
  • Evaluating for underlying medical conditions
  • Sleep testing to assess nighttime disruptions
  • Treatment options to improve sleep quality and symptom management

Better Sleep Starts with Understanding the Cause

Restless leg syndrome can make restful sleep difficult, but understanding what’s causing your symptoms is the first step toward finding relief.

If nighttime discomfort, frequent movement, or ongoing fatigue are affecting your daily life, Sleep Wellness Center is here to help. Our team provides comprehensive sleep evaluations and testing options for patients in Fargo, Grand Forks, and surrounding communities.

Better sleep starts with understanding what’s happening at night and you don’t have to figure it out alone.

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